BioTi: Flow Path biocompatibile

L’hardware in titanio BioTi™ HPLC/UHPLC è progettato per ridurre le interazioni secondarie indesiderate, carry-over e problemi di recupero.

Overlaid Injections–Aggregate Analysis of mAb Sample

BioTi Hardware

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Condizioni per entrambe le colonne:
Column: bioZen 1.8 um SEC-3
Dimensioni: 150 x 4.6 mm
Fase mobile: 50 mM Dipotassium phosphate + 100mM, Sodium Sulfate (pH 5.0)
Flusso: 0,3 ml/min
Injection Volume: 2 µL
Temperature: Ambient
Detection: UV @ 280 nm
Campione: 1. γ-Globulin 5 mg/mL
2. Ovalbumin 1 mg/mL

Traditional Stainless Steel

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Abbiamo progettato il nostro nuovo sistema biocompatibile BioTi per farvi risparmiare ore, giorni e settimane solitamente dedicate al priming delle colonne – Jason Anspach, Ph.D.
Senior Scientist

Extend Column Lifetime with Biocompatible Guard Cartridge Systems

The new biocompatible SecurityGuard Standard and ULTRA cartridge systems remove unwanted contaminants before they clog your column or system. Each bioZen column has a matching guard to ensure workflow applicability.

With a single innovative product line spanning major biologics workflows, you can now gain some reprieve from juggling multiple catalogs, bookmarks, and vendors.With high quality particle chemistries designed and tested for biologics.

Due piattaforme per particelle

Thermally Modified Fully Porous

Micropore
Through a proprietary thermal processing series of steps, we eliminate micropores and further improve consistency, column efficiency, inertness, ruggedness, and reproducibility.
Absence of Micopores

Core-Shell Technology

Porous Shell Non-Porous Core

Uniform Particle Size Distribution

Using sol-gel processing techniques that incorporate nano structuring technology, a durable, homogeneous porous shell is grown on a solid silica core. This highly optimized process combined with industry leading column packing technology produces highly reproducible columns that generate extremely high efficiencies and sensitivity.

Monosized Polymeric Non-Porous

Dual functional non-porous
hydrophilic polymer layer
Non-Porous Core

Uniform Particle Size Distribution

Meticulously controlled monosized particle technology secures incredible particle consistency that leads to improved and reliable efficiency. This innovative non-porous particle serves as the perfect backbone for complex ion-exchange chemistries.

9 Particle Chemistries and Growing

Intatto

Esclusione Dimensionale (SEC)

Peptide

Glycan

Ion-Exchange

bioZen Intact C4
3.6 µm

Particella core-shell ad elevata porosità consente la rapida diffusione del biofarmaco. La fase stazionaria C8 fornisce una selettività idrofobica moderata estremamente utile.

bioZen Intact XB-C8
3.6 µm

Particella core-shell ad elevata porosità per consentire la rapida diffusione del bio-farmaco. i per consentire l’accesso rapidodel farmaco intatto. La fase stazionaria C4 fornisce una bassa ritenzione idrofobica, particolarmente importante per i bio-farmaci altamente ritenuti.

bioZen SEC-3
1.8 µm

Extremely inert, high density fully porous particle with high efficiency and high molecular weight (HMW) separation range of 10 K – 700 kDa.

bioZen SEC-2
1.8 µm

Particella totalmente porosa ultra inerte ad elevata efficienza. Intervallo di separazione : bassi pesi molecolari (LMW) 1K-450 KDa.

bioZen PS-C18
1.6 µm and 3 µm

Eccellente ritenzione mediante combinazione di legante con superficie carica positivamente e legante C18.

bioZen XB-C18
1.7 µm and 2.6 µm

Overall retention of both acidic and basic peptides through C18 stationary phase.

bioZen Glycan
2.6 µm

Offre una combinazione ottimale di elevata efficienza e selettività per i glicani liberi.

bioZen WCX
6 µm

with linear polycarboxylate chains to envelop and separate proteins from acidic/basic variants.