Intact mass can give indications not only of relative abundance of glycoforms, but also stability as degraded mAbs will not give good charge envelope by ESI-MS. Intact Mass with a high resolution MS to identify PTMs, especially relative abundance of glycoforms, combines extremely well with the fast run times and tight peak shapes provided by the bioZen Intact C4 and XB-C8.
Intact Mass of NIST mAb using a bioZen Intact C4 and SCIEX® X500B See Conditions
Spectra NIST mAb
Deconvoluted Spectra NIST mAb
Simplified Biologics Characterization Workflows on the X500B QTOF System
Accelerate your throughput with this easy-to-use benchtop QTOF system that combines robust instrumentation with powerful and intuitive software to get your characterization answers faster and easier.