The bioZen Intact XB-C8 provides an excellent vehicle for determining drug load distribution and DAR for ADCs. Its large pore size allows intact ADCs to interact with a moderately retentive stationary phase while the core-shell particle supplies increased efficiency to deliver the required resolution between ADC species with differing drug loads.
Herceptin—vcMMAE using bioZen 3.6 μm Intact XB-C8 See ConditionsExcellent isomer separation!
Herceptin—mcMMAF using bioZen 3.6 μm Intact XB-C8 See Conditions
We thank ADC Biotechnology LTD for providing ADC samples for this application.